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Rheumatoid factor is an antibody that is directed at the Fc portion of an IgG. It is sensitive for rheumatoid arthritis but not specific, and so if you get a positive rheumatoid factor result, think of other diseases or situations that can cause it to be positive. See the mnemonic above which I learned after Dr. Zickuhr's lecture as referenced below. Rarely, rheumatoid factor can be positive in healthy adults too!
References:Shmerling, R. (2021, April 8). Rheumatoid factor: Biology and utility of measurement. UpToDate. Retrieved February 22, 2022, from https://www.uptodate.com/contents/rheumatoid-factor-biology-and-utility-of-measurement?search=rheumatoid+factor&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1#H4Zickuhr, L. (2021, July 13). 2021 virtual rheumatology practicum - adult (lecture 2) - Approach to Lab Testing - Positive ANA, ENA, RF, CCP, ESR, CRP. YouTube. Retrieved February 22, 2022, from https://www.youtube.com/watch?v=SJjmjaqSubkPublished:February 22, 2022
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