Antiphospholipid Syndrome Diagnosis

Think of you A, B, C's when diagnosing antiphospholipid syndrome. You need one lab and one clinical event as above. Remember that you also need the labs to be positive twice at least 12 weeks apart. This is known as the Sapparo Criteria. Other small clues that you may have APS is that APTT is elevated, mild thrombocytopenia, or a false positive serological syphilis test. It is possible to diagnose APS without meeting the full criteria. Some examples include mild thrombocytopenia, renal thrombotic microangiopathy, and heart valve disease. You may diagnose it if the labs are borderline, but there are clinical events (thrombosis and/or pregnancy events).